منابع مشابه
How integrins control breast biology☆
This article explores new ideas about how the ECM-integrin axis controls normal and malignant breast biology. We discuss the role of integrins in mammary stem cells, and how cell-matrix interactions regulate ductal and alveolar development and function. We also examine the contribution of integrins to tissue disorganisation and metastasis, and how an altered stromal and ECM tumour microenvironm...
متن کاملThe biology of integrins.
Adhesion molecules have traditionally been thought of simply as receptors that permit anchorage to other cells or to the underlying extracellular matrix (ECM). However, within the past decade it has become apparent that adhesion molecules such as integrins mediate critical cytosolic signaling events that have a dramatic impact upon cell proliferation, survival, and motility. Integrins act to re...
متن کاملIntegrins in mammary-stem-cell biology and breast-cancer progression--a role in cancer stem cells?
Cancer cells with stem cell-like properties (cancer stem cells) are believed to drive cancer and are associated with poor prognosis. Data from mouse models have demonstrated that integrins, the major cellular receptors for extracellular-matrix components, have essential roles both during cancer initiation and progression, and during cell differentiation in normal development. By presenting an o...
متن کاملIntegrins control migration style
anen et al. (page 515) show that  1 and  3 integrins direct different types of motility, despite binding fibro-nectin with similar efficiencies. Cells expressing  1 integrin move in a random manner, whereas cells with  3 integrin expression move in a persistent fashion. The proteins control cell migration by altering the activities of the Rho GTPases RhoA and Rac, which in turn control thre...
متن کاملFunction and Regulation of the α6 Integrins in Mammary Epithelial Biology and Breast Cancer: A Dissertation
Integrins have the ability to impact major aspects of epithelial biology including adhesion, migration, invasion, signaling and differentiation, as well as the formation and progression of cancer (Hynes 2002; Srichai and Zent 2010; Anderson et al. 2014). This thesis focuses on how integrins are regulated and function in the context of mammary epithelial biology and breast cancer with a specific...
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ژورنال
عنوان ژورنال: Current Opinion in Cell Biology
سال: 2013
ISSN: 0955-0674
DOI: 10.1016/j.ceb.2013.06.010